Enhancement of the stability of oligonucleotides comprising...

Details Enhancement of the stability of oligonucleotides comprising... Enhancement of the stability of oligonucleotides comprising...

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 31/7088 (2006.01) A61K 31/7125 (2006.01) A61K 47/00 (2006.01) A61K 47/06 (2006.01) A61K 47/18 (2006.01) A61K 47/20 (2006.01) A61K 47/22 (2006.01) A61P 39/06 (2006.01) C09K 15/00 (2006.01)

Patent

CA 2451776

Compositions and methods for inhibition of desulfurization in oligonucleotides comprising one or more phosphorothioate linkages. Antioxidants which partition into the aqueous phase of bi-phasic or multi-phasic topical pharmaceutical formulations inhibit desulfurization of phosphorothioate oligonucleotides, resulting in enhanced oligonucleotide stability.

L'invention concerne des compositions et des procédés pour inhiber la désulfuration dans des oligonucléotides comprenant une ou plusieurs liaisons phosphorothioate. Les antioxydants qui se séparent à l'intérieur de la phase aqueuse de formulations pharmaceutiques topiques biphasiques ou multiphasiques inhibent la désulfuration des oligonucléotides à liaisons phosphorothioate, ce qui améliore la stabilité de ces oligonucléotides.

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