A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/535 (2006.01) A61K 9/70 (2006.01) A61K 31/40 (2006.01) A61K 47/24 (2006.01)
Patent
CA 2184198
Pharmaceutical formulations, transdermal drug delivery devices, and methods of drug delivery using the formulations and devices of the invention are disclosed which make it possible to enhance the rate of transdermal drug delivery of pharmaceutically active compounds and in particular molsidomine. The rate of drug delivery is increased by using absorption promoters which include monoalkyl phosphates and salts thereof alone or in combination with other absorption promoters such as polyhydroxyl esters, longchain fatty acids, polyhydroxyl alcohols and terpenes. Particular combinations of monoalkyl phosphates with one or more additional absorption promoters provide synergistic effects with respect to enhancing the rate of drug delivery of certain pharmaceutically active drugs such as molsidomine.
L'invention décrit des formulations pharmaceutiques, des dispositifs d'apport transdermique de médicaments et des procédés d'apport médicamenteux à l'aide de formulations et de dispositifs décrits par l'invention, qui permettent d'améliorer la vitesse d'apport transdermique de médicaments de composés actifs sur le plan pharmaceutique et en particulier de la molsidomine. La vitesse d'apport de médicaments est augmentée par des activateurs d'absorption qui comprennent des phosphates monoalkyles et leurs sels, employés seuls, ou associés à d'autres activateurs d'absorption tels quedes esters polyhydroxylés, acides gras à longue chaîne, alcools polyhydroxylés et terpènes. Des associations particulières de phosphates monoalkyles avec un ou plusieurs autres activateurs d'absorption produisent des effets synergiques concernant l'amélioration de la vitesse d'apport médicamenteux de certains médicaments actifs sur le plan pharmaceutique tels que la molsidomine.
Nguyen Thuytien N.
Wong Ooi
Cygnus Inc.
Cygnus Inc.
Cygnus Therapeutic Systems
Dimock Stratton Clarizio Llp
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