Enhancing coagulation or reducing fibrinolysis

Details Enhancing coagulation or reducing fibrinolysis Enhancing coagulation or reducing fibrinolysis

A - Human Necessities

61

K

A61K 31/416 (2006.01) A61K 31/69 (2006.01) A61K 45/06 (2006.01) A61P 7/04 (2006.01) A61P 9/12 (2006.01)

Patent

CA 2754549

Methods for controlling bleeding (e.g., enhancing coagulation and reducing fibrinolysis) in a subject are disclosed. The methods include selecting a subject in need of enhanced coagulation or reduced fibrinolysis, and administering to the subject a carbon monoxide releasing molecule (CORM). Examples of CORMs include tricarbonyldichloro-ruthenium (II) dimer, tricarbonylchloro-(glycinato)ruthenium (II), sodium boranocarbonate, dimanganese decacarbonyl, and iron pentacarbonyl. Further disclosed are compositions and methods for treating a subject in need of a blood product by administering to the subject a composition including a CORM and a blood product (e.g., cryoprecipitate or fresh frozen plasma).

L'invention porte sur des procédés de régulation du saignement (par exemple, l'amélioration de la coagulation et la réduction de la fibrinolyse) chez un sujet. Les méthodes consistent à sélectionner un sujet nécessitant une meilleure coagulation ou une fibrinolyse réduite, et à administrer au sujet une molécule libérant du monoxyde de carbone (CORM). Des exemples de CORM comprennent un dimère tricarbonyldichloro-ruthénium (II), du tricarbonylchloro-(glycinato)ruthénium (II), du boranocarbonate de sodium, du décacarbonyle de dimanganèse, et du pentacarbonyle de fer. L'invention porte en outre sur des compositions et des méthodes de traitement d'un sujet nécessitant un produit sanguin par administration au sujet d'une composition comprenant un CORM et un produit sanguin (par exemple, un cryoprécipité ou du plasma congelé frais).

Affiliated with

Also associated with

Rating

Enhancing coagulation or reducing fibrinolysis does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Enhancing coagulation or reducing fibrinolysis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Enhancing coagulation or reducing fibrinolysis will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1915354