C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/861 (2006.01) A61K 31/711 (2006.01) A61K 38/16 (2006.01) A61K 38/17 (2006.01) A61K 39/12 (2006.01) A61K 39/145 (2006.01) A61K 48/00 (2006.01) A61P 31/12 (2006.01) A61P 31/16 (2006.01) C12N 7/01 (2006.01)
Patent
CA 2666357
The present disclosure provides compositions and methods for enhancing resistance to viral infections. The compositions include adenovirus vectors containing nucleic acid molecules encoding CARD domains from RIG-I and MDA5, recombinant adenoviruses and immunogenic compositions comprising such recombinant adenovirus vectors and adenoviruses. Methods for enhancing resistance to viral infections involving administering such adenovirus vectors or recombinant adenovirus are also provided.
L'invention concerne des compositions et des procédés pour augmenter la résistance à des infections virales. Les compositions comprennent des vecteurs adénovirus contenant des molécules d'acide nucléique codant pour des domaines de CARD à partir de RIG-I et de MDA5, des adénovirus recombinants et des compositions immunogènes comprenant de tels vecteurs adénovirus et de tels adénovirus recombinants. Des procédés pour augmenter la résistance aux infections virales impliquant l'administration de tels vecteurs adénovirus ou de tels adénovirus recombinants sont également fournis.
Guo Zhu
Sambhara Suryaprakash
Smart & Biggar
The Government Of The United States Of America As Represented By Centers For Disea
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