Enhancing host immunity against viral infections

A - Human Necessities – 61 – K

Patent

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A61K 38/21 (2006.01) A61K 31/135 (2006.01) A61K 38/20 (2006.01)

Patent

CA 2180193

Cell mediated immunity against persistent viral infection in a host is potentiated by administering to the host an effective amount of at least one antiestrogen capable of enhancing cytotoxic T lymphocytes in the host, such as a triphenylethylene tamoxifen, particularly tamoxifen or toremifene. This administration leads to the elimination of all infected cells and to the complete clearance of virus and virus induced tumor cells from the body, leaving protective cell mediated immunity. This therapy requires MHC restricted virus specific CTLs which then will kill virus infected very specifically, which may be initially present or formed in vivo or in vitro. The effect of the antiestrogen may be enhanced by the use of interferons optionally with indomethacin.

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