Enhancing keratinocyte migration and proliferation

Details Enhancing keratinocyte migration and proliferation Enhancing keratinocyte migration and proliferation

C - Chemistry, Metallurgy

12

N

C12N 5/071 (2010.01) A61K 38/18 (2006.01) A61K 38/48 (2006.01)

Patent

CA 2225898

A method of enhancing the migration and proliferation of keratinocytes in wound healing or in the growth of artificial skin grown in vitro. The wound is contacted with (a) an effective amount of purified Clostridiopeptidase A collagenase that is substantially free from other proteinases and (b) an amount of a growth factor that increases the effects of said collagenase. The artificial skin is grown upon biomatrices previously synthesized by living cells and digested with Clostridiopeptidase A collagenase while in the presence of (a) an effective concentration of purified Clostridiopeptidase A collagenase substantially free from other proteinases and (b) a growth factor in a concentration effective to increase the effectiveness of said collagenase.

Méthod pour l'amélioration de la migration et de la prolifération des kératinocytes dans la guérison des blessures ou dans la croissance in vitro de la peau artificielle. La blessure est mise en contact avec a) une quantité appropriée de clostridiopeptidase-A-collagénase purifiée à peu près exempte d'autres protéinases et b) une quantité d'un facteur de croissance qui augmente les effets de cette collagénase. La peau artificielle croît sur des biomatrices préalablement syntétisées par des cellules vivantes et digérées par le clostridiopeptidase-A-collagenase en présence a) d'une concentration efficace de clostridiopeptidase purifiée à peu près exempte d'autres protéinases et b) un facteur de croissance à une concentration appropriée pour accroître l'efficacité de ladite collagénase.

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