Enhancing the circulating half-life of interleukin-2 proteins

Details Enhancing the circulating half-life of interleukin-2 proteins Enhancing the circulating half-life of interleukin-2 proteins

C - Chemistry, Metallurgy

07

K

C07K 14/55 (2006.01) C12N 5/10 (2006.01)

Patent

CA 2536868

The present invention relates generally to novel interleukin-2 proteins, including fusion proteins, based on two or more amino acids alterations in the N-terminal region of the IL-2 protein, and, more specifically, to methods of enhancing the circulating half-life by means of these interleukin-2 proteins.

L'invention concerne de manière générale de nouvelles protéines de type interleukine-2 (IL-2), parmi lesquelles figurent des protéines de fusion, cette invention étant fondée sur l'altération de deux acides aminés, ou davantage, dans la région N-terminale d'une protéine IL-2. La présente invention se rapporte de manière plus spécifique à des procédés pour augmenter la demi-vie circulante au moyen desdites protéines de type interleukine 2.

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