Enhancing the sensitivity of tumor cells to therapies

A - Human Necessities – 61 – K

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A61K 48/00 (2006.01) A61K 31/70 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 14/715 (2006.01) C07K 14/82 (2006.01) C12N 15/85 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2189032

A method for enhancing the effect of a cancer the introducing wild-type therapy sensitizing gene activity into tumor cells having mutant therapy sensitizing gene activity and subjecting the tumor cells to a cancer therapy such as chemotherapy, radiotherapy, biological therapy including immunotherapy, cryotherapy and hyperthermia.

L'invention concerne un procédé d'amélioration de l'effet d'une thérapie du cancer consistant à introduire une activité génique de type sauvage de sensibilisation à une thérapie dans des cellules tumorales présentant une activité génique mutante de sensibilisation à une thérapie, et à soumettre les cellules tumorales à une thérapie du cancer telle qu'une chimiothérapie, une radiothérapie, une thérapie biologique, y compris une immunothérapie, une cryothérapie et une hyperthermie.

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