Enhancing therapeutic effectiveness of nitric oxide inhalation

Details Enhancing therapeutic effectiveness of nitric oxide inhalation Enhancing therapeutic effectiveness of nitric oxide inhalation

A - Human Necessities

61

K

A61K 33/00 (2006.01) A61K 31/198 (2006.01) A61K 31/381 (2006.01) A61K 31/404 (2006.01) A61K 31/47 (2006.01) A61P 11/00 (2006.01)

Patent

CA 2414409

Methods for reducing, partially preventing or completely preventing nitric oxide (NO) inhalation-related impairment of HPV in a mammal are disclosed. The methods include administering a therapeutically effective amount of NO by inhalation, and co-administering an effective amount of an anti-reactive oxygen species (anti-ROS) agent, e.g., N-acetyl-cysteine, or a leukotriene blocker. Methods for reducing, partially preventing or completely preventing loss of pulmonary vasodilatory responsiveness to NO inhalation in a mammal are also disclosed. The methods include administering a therapeutically effective amount of NO by inhalation, and co-administering an effective amount of an anti ROS agent a therapeutically effective amount of a leukotriene blocker.

L'invention concerne des méthodes qui permettent de réduire, ou d'empêcher partiellement ou complètement une déficience de HPV liée à l'inhalation du monoxyde d'azote (NO) chez un mammifère. Ces méthodes consistent à administrer par inhalation une quantité thérapeutiquement effective de NO, et à coadministrer une quantité thérapeutiquement effective d'un agent de l'espèce d'oxygène antiréactive (anti-ROS), tel que N-acétyl-cystéine ou un bloquant de la leucotriène. L'invention concerne des méthodes qui permettent de réduire, ou d'empêcher partiellement ou complètement la perte de réaction de vasodilatation pulmonaire liée à l'inhalation de NO chez un mammifère. Ces méthodes consistent à administrer par inhalation une quantité thérapeutiquement effective de NO, et à coadministrer une quantité thérapeutiquement effective d'un agent anti-ROS et une quantité thérapeutiquement effective d'un bloquant de la leucotriène.

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