Enkephalin analogues

C - Chemistry – Metallurgy – 07 – C

Patent

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530/7.12

C07C 275/14 (2006.01) C07K 5/107 (2006.01) C07K 14/70 (2006.01)

Patent

CA 1145330

A B S T R A C T Tetrapeptide amides of the formula Image wherein R1, R8, Rx, B and D represent certain specified substituent groups. The compounds exhibit pharmacological activity when tested in vitro in the transmurally stimulated guinea pig ileum preparation indicating their affinity for opiate receptor sites, and also in vivo tests, with intravenous administration, indicating their analgesic effects, and hence their utility as analgesic agents.

317174

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