Enkephalin derivatives

Details Enkephalin derivatives Enkephalin derivatives

C - Chemistry, Metallurgy

07

D

530/7.12

C07D 241/08 (2006.01) C07K 5/078 (2006.01) C07K 5/117 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1161838

M-1062-C1 ABSTRACT Novel analgesic and antipsychotic agents having the formula Image wherein Q is Image or Image in which R1 is hydrogen, hydroxy or halogen and R4 is hydrogen or, R1 and R4 are both hydroxy; Z is hydrogen or straight chain lower alkyl having from 1 to 4 carbon atoms and X is methylene, carbonyl, hydroxymethylene, thio, sul- finyl or sulfonyl, or Z and X, taken together, are methyli- denyl, with the proviso that when X is sulfonyl or sulfinyl, Z is other than hydrogen; R5 is hydrogen or halogen, and R2 is H, a straight or branched lower alkyl group having from 1 to 4 carbon atoms, the group Image or the group Image , wherein R3 is hydroxy, amino, alkylamino or di- alkylamino wherein the alkyl moiety is straight or branched and has from 1 to 4 carbon atoms, diastereomers, enantio- mers and pharmaceutically acceptable salts thereof.

353383

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