Enkephalinase b inhibitors, their preparation, and...

Details Enkephalinase b inhibitors, their preparation, and... Enkephalinase b inhibitors, their preparation, and...

C - Chemistry, Metallurgy

07

K

530/5.06, 195/12

C07K 5/06 (2006.01) C07K 5/078 (2006.01) C12P 21/02 (2006.01)

Patent

CA 1277623

ABSTRACT OF THE DISCLOSURE Propioxatins A and B, which have the formula: Image wherein R represents a hydrogen atom or a methyl group, can be prepared by cultivating a suitable strain of Kitasatosporia, e.g. Kitasatoporia sp. SANK 60684 (FERM-P 7581). They can be salified to give pharmaceutically acceptable salts. The compounds are active as enkephalinase B inhibitors and are thus capable of enhancing enkephalin activity in vivo.

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