Enkephalinase inhibitors

Details Enkephalinase inhibitors Enkephalinase inhibitors

C - Chemistry, Metallurgy

07

C

167/179, 260/385

C07C 323/60 (2006.01) A61K 31/22 (2006.01) C07C 233/16 (2006.01) C07C 327/34 (2006.01)

Patent

CA 1298307

ER28 ABSTRACT ENKEPHALINASE INHIBITORS Inhibition of enkephalinase activity in mammals is achieved by the present novel compounds having the formula Image and pharmaceutically acceptable salts thereof, wherein R1 is hydrogen or R5-?-, wherein R5 is alkyl, aryl, arylalkyl, heteroaryl, or (heteroaryl)alkyl; R2 and R3 are each independently hydrogen, alkyl, (cycloalkyl)alkyl, aryl, arylalkyl, heteroaryl, or (heteroaryl)alkyl; R4 is hydroxy, alkoxy, arylalkoxy, (hetero- aryl)alkoxy, (substituted alkyl)oxy, or -NR6R7, wherein R6 and R7 are each independently hydrogen, alkyl, substituted alkyl, aryl, arylalkyl, or (heteroaryl)alkyl; and n is an integer of 1 to 15.

477725

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