A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 36/47 (2006.01) A61K 9/22 (2006.01) A61K 9/58 (2006.01) A61K 31/765 (2006.01) A61K 36/38 (2006.01) A61P 1/12 (2006.01)
Patent
CA 2269078
Pharmaceutical compositions containing a proanthocyanidin polymer composition which are useful for the treatment and prevention of secretory diarrhea are provided. The invention specifically relates to pharmaceutical formulations of a proanthocyanidin polymer composition which has been isolated from a Croton spp. or a Calophyllum spp. In particular, the invention relates to a formulation of a proanthocyanidin polymer composition which protects the composition from the effects of stomach acid after oral administration, particularly to those formulations which are enteric coated. Methods for use of the formulations as well as methods for use of the proanthocyanidin polymer composition in combination with an effective amount of a compound effective either to inhibit secretion of stomach acid or to neutralize stomach acid are disclosed.
La présente invention concerne des compositions pharmaceutiques contenant une composition polymère pro-anthocyanidine convenant parfaitement au traitement et à la prévention d'une diarrhée sécrétoire. L'invention concerne, en particulier, des formulations pharmaceutiques d'une composition polymère pro-anthocyanidine, isolée à partir d'un Croton spp ou d'un Calophyllum spp. La présente invention concerne, également, une formulation d'une composition polymère pro-anthocyanidine protégeant ladite composition contre les acides gastriques, après administration orale, et en particulier les compositions kératinisées. La présente invention concerne, enfin, des procédés d'utilisation des formulations ainsi que des procédés d'utilisation de la composition polymère pro-anthocyanidine en combinaison avec une quantité efficace d'un composé efficace en vue soit d'inhiber la sécrétion d'acide gastrique soit de neutraliser ledit acide gastrique.
Khandwala Atul S.
Rozhon Edward J.
Sabouni Akram
Napo Pharmaceuticals Inc.
Osler Hoskin & Harcourt Llp
Shaman Pharmaceuticals Inc.
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