Enterococcus antigens and vaccines

Details Enterococcus antigens and vaccines Enterococcus antigens and vaccines

A - Human Necessities

61

K

A61K 39/145 (2006.01) C07K 16/12 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2306476

A majority of E. faecalis and E. faecium clinical isolates fall into two groups and three groups, respectively. Distinct antigens are associated with each of the five groups. The Enterococcus antigens are readily obtained from strains of E. faecalis and E. faecium, and can elicit production of protective antibodies. Accordingly, the antigens are useful for vaccines which protect against infection by clinically significant (pathogenic) Enterococcus isolates. The antigens and antibodies generated to the antigens are also useful in diagnostic assays.

La majorité des isolats cliniques d'E. faecalis et d'E. faecium se divisent respectivement en deux et trois groupes. Des antigènes distincts sont associés à chacun des cinq groupes. Les antigènes d'Enterococcus, obtenus directement à partir de souches d'E. faecalis et d'E. faecium, peuvent induire la production d'anticorps protecteurs. Ces antigènes sont donc utiles pour fabriquer des vaccins qui protègent contre l'infection par des isolats d'Enterococcus cliniquement significatifs (pathogènes). Les antigènes et les anticorps produits par lesdits antigènes sont également utiles pour des analyses diagnostiques.

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