Entrapped stem cells and uses thereof

Details Entrapped stem cells and uses thereof Entrapped stem cells and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 5/0735 (2010.01) C12N 5/071 (2010.01) A61K 35/12 (2006.01) A61K 47/36 (2006.01) A61K 47/42 (2006.01) A61L 27/38 (2006.01) A61P 35/00 (2006.01) C12N 11/00 (2006.01)

Patent

CA 2537861

The invention relates to the stem cells, embryonic stem cells in particular. It has been found that, when these stem cells are entrapped such that their proliferation is inhibited, they produce material which inhibits the proliferation of other, non-entrapped cells, including stem cells and neoplastic and/or hyperproliferative, but otherwise normal cells. It has also been found that entrapped cancer cells will produce material which inhibits the proliferation of stem cells. Further, it has been found that the entrapment of the stem cells inhibits their differentiation and thus the entrapment process can serve as a long-term storage device for maintaining the undifferentiated state of at least a portion of the entrapped cells.

L'invention concerne des cellules souches, en particulier des cellules souches embryonnaires. Lorsque les cellules souches sont piégées, de sorte que leur prolifération est inhibée, elles produisent une matière qui inhibe la prolifération des autres cellules non piégées, notamment des cellules souches, des cellules néoplastiques et/ou hyperproliférantes, mais également des cellules normales. Les cellules cancéreuses piégées produisent une matière qui inhibe la prolifération des cellules souches. Le piégeage des cellules souches inhibe leur différentiation et le procédé de piégeage peut être utilisé dans un dispositif de stockage à long terme, de manière à maintenir un état non différencié d'au moins une partie des cellules piégées.

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