Entry inhibitors of the hiv virus

Details Entry inhibitors of the hiv virus Entry inhibitors of the hiv virus

C - Chemistry, Metallurgy

07

D

C07D 217/02 (2006.01) A61K 31/16 (2006.01) A61K 31/34 (2006.01) A61K 31/472 (2006.01) A61P 31/18 (2006.01) C07C 237/04 (2006.01) C07C 311/21 (2006.01) C07C 311/29 (2006.01) C07D 295/14 (2006.01) C07D 307/68 (2006.01) C07D 317/68 (2006.01) C07D 413/06 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2531766

The present invention relates to small molecules as entry inhibitors of the HIV virus, processes for their preparation as well as pharmaceutical compositions, their use as medicines, and diagnostic kits comprising them. The present invention also concerns combinations of the present entry inhibitors with other anti-retroviral agents. It further relates to their use in assays as reference compounds or as reagents. The compounds of the present invention are useful for preventing or treating infection by HIV and for treating AIDS. The compounds of formula (I) have the following structure: (I).

La présente invention concerne de petites molécules qui sont utilisées comme inhibiteurs de la pénétration du virus VIH, des procédés pour les préparer et des compositions pharmaceutiques, leur utilisation comme médicaments, et des kits de diagnostic qui les comprennent. L'invention a également pour objet des combinaisons des inhibiteurs de pénétration de l'invention avec d'autres agents anti-rétroviraux et leur utilisation dans des essais en tant que composés ou que réactifs. Les composés de l'invention sont utiles pour prévenir ou traiter l'infection par le VIH et pour traiter le SIDA. Les composés de l'invention ont une structure définie par la formule (I).

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