Env polypeptide complexes and methods of use

Details Env polypeptide complexes and methods of use Env polypeptide complexes and methods of use

C - Chemistry, Metallurgy

07

K

C07K 14/705 (2006.01) C07K 14/16 (2006.01)

Patent

CA 2570043

Provided herein are small molecule CD4 mimetics effective to bind to HIV Env proteins. A CD4 mimetic of the invention, when bound to an Env protein, is effective to induce a conformational change in the Env protein such that cyptic epitopes on the Env protein are exposed. Also provided herein are related methods of identifying and using such small molecule CD4 mimetics, for example, to elicit an immune response in a subject upon administration.

La présente invention concerne des mimétiques CD4 à petite molécule qui se lient efficacement aux protéines Env VIH. Un mimétique CD4 selon l'invention, une fois lié à une protéine Env, est efficace pour induire une modification conformationnelle de la protéine Env telle que les épitopes cryptiques de la protéine Env soient exposés. Cette invention porte également sur des méthodes d'identification et d'utilisation de ces mimétiques CD4 à petite molécule, par exemple, pour éliciter une réponse immunitaire chez un sujet suite à l'administration.

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