C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/04 (2006.01)
Patent
CA 2599852
Environmentally stable biosensors are disclosed, which comprise a ligand binding domain from a thermophilic organism conjugated to donor and fluorescent moieties that permit detection and measurement of Fluorescence Resonance Energy Transfer upon ligand binding. Such biosensors demonstrate enhanced acid-, thermal- and chemical stability as compared to sensors constructed using protein domains from mesophilic organisms.
La présente invention décrit des biocapteurs stables dans l~environnement, qui comprennent un domaine de liaison de ligand provenant d~un organisme thermophile conjugué à un donneur et de groupements fluorescents qui permettent la détection et la mesure du transfert d~énergie par résonance de fluorescence qui se produit lors de la liaison du ligand. De tels biocapteurs montrent une stabilité améliorée aux acides, à la chaleur et aux produits chimiques, comparativement aux capteurs construits en utilisant des domaines de protéines d'organismes mésophiles.
Frommer Wolf B.
Looger Loren
Carnegie Institution Of Washington
Gowan Intellectual Property
LandOfFree
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