Enzymatic acylation to afford .beta.-lactam antibiotics

Details Enzymatic acylation to afford .beta.-lactam antibiotics Enzymatic acylation to afford .beta.-lactam antibiotics

C - Chemistry, Metallurgy

12

P

195/96

C12P 37/00 (2006.01) C12P 35/04 (2006.01)

Patent

CA 1049431

Enzymatic Acylation to afford .beta.-Lactam Antibiotics ABSTRACT Penicillin or cephalosporin antibiotics represented by fol- lowing formula: Image , or Image [where R?- is an acyl group derived from an .alpha.-amino acid, N- ammonium salt of .alpha.-amino acid, or N-(C1 to C10) acyl-.alpha.-amino acid; COOM is carboxy or carboxylate salt group] are prepared by treating an amino compound selected rom a group consisting of 6-aminopenicillanic acid, 7-aminocephalosporanic acid, 7-amino- deacetoxycephalosporanic acid, and their salts with an ester represented by following formula: RCOOR1 [where R?- is as defined above and R1 is a (C1 to C10) alkyl group] by enzymatic acylation effected with mycelium or mycelium preparation from a microorganism belonging to genus Aphanocladium or Cephalosporium.

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