Enzymatic preparation of 3',4'-anhydrovinblastine

Details Enzymatic preparation of 3',4'-anhydrovinblastine Enzymatic preparation of 3',4'-anhydrovinblastine

C - Chemistry, Metallurgy

12

P

195/131, 195/39

C12P 17/18 (2006.01) C07D 519/04 (2006.01)

Patent

CA 1290270

ABSTRACT OF THE DISCLOSURE 3',4'-anhydrovinblastine, a precursor of the anti-tumor alkaloids vincristine and vinblastine, is prepared by the enzymatic coupling of catharanthine and vindoline using an iron-containing compound such as peroxidase optionally in the presence of a peroxide. Substantially enhanced yields are obtained.

543675

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