Enzymatic process for obtaining 17 alpha-monoesters of...

C - Chemistry – Metallurgy – 12 – P

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C12P 33/00 (2006.01) A61K 31/573 (2006.01) A61P 5/28 (2006.01) C07J 5/00 (2006.01)

Patent

CA 2691445

The present invention refers to an enzymatic process for obtaining 17alpha- monoesters of cortexolone and/or its 9, 11-dehydroderivatives starting from the corresponding 17alpha, 21-diesters which comprises an enzymatic alcoholysis reaction. Furthermore, the present invention refers to crystalline forms of cortexolone 17alpha-propionate and 9,11-dehydro-cortexolone 17alpha-butanoate.

La présente invention porte sur un nouveau procédé enzymatique pour obtenir des 17a-monoesters de cortexolone et/ou ses dérivés 9,11-déshydro, en partant des 17a,21-diesters correspondants. Ce procédé comprend une réaction d'alcoolyse enzymatique. De plus, la présente invention porte sur de nouvelles formes cristallines de 17a-propionate de cortexolone et de 17a-butanoate de 9,11-déshydro-cortexolone.

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