Enzymatic process for the enantiomeric resolution of amino...

Details Enzymatic process for the enantiomeric resolution of amino... Enzymatic process for the enantiomeric resolution of amino...

C - Chemistry, Metallurgy

12

P

C12P 13/04 (2006.01) C12N 9/80 (2006.01) C12P 41/00 (2006.01)

Patent

CA 2459246

The invention relates to a novel enzymatic method that is used for the enantiomeric resolution of amino acids. More specifically, said method of separating the enantiomers of an amino acid consists in treating a racemic mixture of said amino acid with glutaric anhydride and subsequently with the Glutaryl 7-ACA acylase enzyme such that one of the enantiomers of said amino acid is recovered, while the other enantiomer remains in the form of a derivative of the corresponding glutaryl amide.

La présente invention se rapporte à un nouveau procédé enzymatique permettant la résolution énantiomérique d'acides aminés. Plus précisément, ce procédé de séparation des énantiomères d'un acide aminé consiste à traiter un mélange racémique dudit acide aminé avec de l'anhydride glutarique puis avec l'enzyme Glutaryl 7-ACA acylase de sorte que l'on récupère l'un des énantiomères dudit acide aminé, l'autre énantiomère restant sous forme du dérivé de l'amide glutaryle correspondant.

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