Enzymatic process to separate racemic mixtures of delta...

C - Chemistry – Metallurgy – 12 – P

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C12P 41/00 (2006.01) C07D 309/30 (2006.01) C12P 17/02 (2006.01) C12P 17/06 (2006.01)

Patent

CA 2096597

Abstract Process to separate racemic mixtures of beta-hydroxy or beta-acyloxy-delta-valerolactones, which in position 2 and/or 5 of the lactone ring are substituted by hydrogen, alkyl groups having 4 to 20 C atoms, which are optionally penetrated by an oxygen atom, or by aralkyl groups, whereby not both positions are substituted by hydrogen, through reaction of the racemic mixture in the presence of a hydrolase with or without esterifying agent in a diluent and separation of the reaction mixture, which contains an enantiomerically pure beta-hydroxy-delta-valerolactone and an enantiomerically pure beta-acyloxy-delta-valerolactone, through conventional methods into the enantiomically pure compounds, a process fox the manufacture of enantiomerically pure oxetanones using said separation process and enantiomerically pure beta-acyloxy-delta-valerolactones. 27

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