Enzymatic processes for the production of 4-substituted...

Details Enzymatic processes for the production of 4-substituted... Enzymatic processes for the production of 4-substituted...

C - Chemistry, Metallurgy

12

N

C12N 9/14 (2006.01) C12P 7/52 (2006.01) C12P 7/62 (2006.01) C12P 13/00 (2006.01)

Patent

CA 2493941

The present invention provides methods and compositions for preparing 4- substituted 3-hydroxybutyric acid derivatives by halohydrin dehalogenase- catalyzed conversion of 4-halo-3-hydroxybutyric acid derivatives. The present invention further provides methods and compositions for preparing 4-halo-3- hydroxybutyric acid derivatives by ketoreductase-catalyzed conversion of 4- halo-3-ketobutyric acid derivatives.

La présente invention concerne des méthodes et des compositions utilisés pour la préparation de dérivés de 3-acide hydroxybutyrique substitué en position 4 par transformation catalysée par halohydrine déshydrogénase de dérivés de 4-halo-3-acide hdroxybutyrique. L'invention concerne également des méthodes et des compositions permettant d'obtenir des dérivés de 4-halo-3-acide hydroxybutyrique par transformation catalysée par cétoréductase de dérivés de 4-halo-3-acide cétobutyrique.

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