Enzymatic removal of a protein amino-terminal sequence

Details Enzymatic removal of a protein amino-terminal sequence Enzymatic removal of a protein amino-terminal sequence

C - Chemistry, Metallurgy

12

P

530/7.1, 195/128

C12P 21/06 (2006.01) C07K 14/62 (2006.01)

Patent

CA 2016049

X-7318 Abstract of the Disclosure This disclosure relates to new compounds and to a process for the controlled conversion of such com- pounds to produce a Protein that comprises an amino acid sequence which is useful as a precursor to human insulin or to a modified human insulin, the amino terminus por- tion of which sequence does not define a cathepsin C dipeptide removal stop point. The compounds have the formula Met-Y-Protein in which Y is Tyr or Arg.

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