Enzymatic resolution of aminotetralins

C - Chemistry – Metallurgy – 12 – P

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C12P 41/00 (2006.01) C07C 233/23 (2006.01) C12P 13/02 (2006.01)

Patent

CA 2307390

Stereoisomers of carbocyclic amine compounds such as amino tetralins are separated by subjecting a mixture of the stereoisomers to reaction with an acylating agent in the presence of the enzyme Pseudomonas capacia lipase which effect selective acylation of one of the stereoisomers to form a separable amide, whilst leaving the other stereoisomer substantially unchanged.

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