Enzymatic resolution of endo-bicyclo¬2.2.1|heptan-2-ol and...

Details Enzymatic resolution of endo-bicyclo¬2.2.1|heptan-2-ol and... Enzymatic resolution of endo-bicyclo¬2.2.1|heptan-2-ol and...

C - Chemistry, Metallurgy

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C12P 41/00 (2006.01) A61K 31/495 (2006.01) C07C 45/71 (2006.01) C07C 47/575 (2006.01) C07C 235/34 (2006.01) C07C 255/37 (2006.01) C07C 255/38 (2006.01) C07D 239/10 (2006.01) C12P 7/02 (2006.01) C12P 17/12 (2006.01)

Patent

CA 2029705

Process for the pancreatic lipase mediated trans-esterification method for the optical resolution of endo-norborneol; derived optically active 5-(3-(exo- bicyclo[2.2.1]hept-2-yloxy)-4-methoxyphenyl)-3,4,5,6- tetrahydropyrimidin-2(1H)-ones; and stepwise process and intermediates therefor.

Méthode de transestérification via la lipase pancréatique, pour la résolution optique de l'endo-norbornéol; 5-(3-(exo- bicyclo¢2.2.1!hept-2-yloxy)-4-méthoxyphényl)-3,4,5,6- tétrahydropyrimidin-2(1H)-ones, dérivés optiques; procédé séquentiel et intermédiaires à cette fin.

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