Enzymatic resolution of substituted 2-methyl-propionic acid

Details Enzymatic resolution of substituted 2-methyl-propionic acid Enzymatic resolution of substituted 2-methyl-propionic acid

C - Chemistry, Metallurgy

12

P

C12P 41/00 (2006.01) C12P 7/40 (2006.01) C12P 7/52 (2006.01) C12P 7/62 (2006.01) C12P 13/00 (2006.01)

Patent

CA 2183449

Provided are enzymatic methods for the selective hydrolytic resolution of certain enantiomers of a pharmaceutical compound, the pharmaceutical compound comprising a () mixture of a .alpha.-substituted 2-methyl propionic acid derivative. Specifically provided is the selective enzymatic resolution of either the R(+) or S(-) enantiomer of ()- ethyl ciprofibrate. Also provided are substantially pure enantiomers of R(+) and S(-) ciprofibrate.

L'invention porte sur un procédé enzymatique de résolution hydrolytique sélective de certains énantiomères d'un composé pharmaceutique comprenant un mélange (~) de dérivés de l'acide méthyl-2 propionique à substitution .alpha., et en particulier procédé enzymatique de résolution sélective de l'un des énantiomères R(+) ou de S(-) du ciprofibrate d'éthyle (~). L'invention porte également sur les énantiomères R(+) ou S(-) dudit ciprofibrate.

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