Enzymatic splitting of alkyl piperidine-2-carboxylates and...

Details Enzymatic splitting of alkyl piperidine-2-carboxylates and... Enzymatic splitting of alkyl piperidine-2-carboxylates and...

C - Chemistry, Metallurgy

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P

C12P 41/00 (2006.01) A61K 31/445 (2006.01) C07D 211/22 (2006.01) C07D 211/60 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01) C07K 5/078 (2006.01) C12P 17/12 (2006.01)

Patent

CA 2116833

DEDOUBLEMENT ENZYMATIQUE DE PIPERIDINE-2-CARBOXYLATES D'ALKYLE ET UTILISATION DES COMPOSES OBTENUS COMME INTERMEDIAIRES DE SYNTHESE SYNTHELABO Abrégé descriptif Procédé de préparation de (2R-trans)-pipéridine-2- carboxylates d'alkyle de formule (1) Image (1) dans laquelle R représente un groupe (C1-C3)alcoxy et R3 représente un groupe (C1-C3)alkyle, procédé selon lequel on fait réagir une pipéridine-2-carboxylate d'alkyle sous forme de racémate de configuration trans, avec une enzyme qui dégrade spécifiquement l'énantiomère (2S-trans) en laissant sensiblement intact l'énantiomère (2R-trans).

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