C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 13/00 (2006.01) A61K 9/10 (2006.01) A61K 9/127 (2006.01) C07F 9/10 (2006.01) C12P 7/64 (2006.01) C12P 9/00 (2006.01)
Patent
CA 2080907
A method of preparing a soluble monovalent salt of a phosphatidyl ester which comprises reacting a phospholipid with a primary alcohol in the presence of an enzyme catalyst in a divalent cationic buffered solution and a water immiscible non-ether solvent that does not inactivate the enzyme, to form a divalent cationic salt of the phosphatidyl ester, and suspending the product in the presence of a stoichiometric amount of a monovalent cationic salt whose anion forms an insoluble salt with the divalent cation. The use of Centrifugal Partition Chromatography facilitates the enzyme reaction. The monovalent salt is preferably an ammonium/sodium mixed salt. Phosphatidyl ester salts prepared by processes disclosed herein are useful products for making liposomes and lipid-based complexes.
Marziani Frank
Pilkiewicz Frank G.
Tino John A.
Tremblay Paul A.
Elan Pharmaceuticals Inc.
Osler Hoskin & Harcourt Llp
The Liposome Company Inc.
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