A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01)
Patent
CA 2369999
The present invention relates to a polymeric drug conjugate with one or more biologically active agents conjugated via an enzymatically cleavable linker to either a regular repeating linear unit comprising a water soluble polymer segment and a multifunctional chemical moiety, or a branched polymer comprising two or more water soluble polymer segments each bound to a common multifunctional chemical moiety, as well as to methods of making such conjugates. The present invention is also directed to pharmaceutical compositions comprising such conjugates and to the use of such conjugates to treat pathological conditions.
La présente invention concerne un conjugué de médicament polymère contenant au moins un agent actif d'un point de vue biologique conjugué via un bras clivable par voie enzymatique soit à un motif linéaire régulier répétitif contenant un segment polymère hydrosoluble et un fragment chimique multifonctionnel, soit à un polymère ramifié comprenant au moins deux segments polymères hydrosolubles liés chacun à un fragment chimique multifonctionnel commun. L'invention concerne également des procédés d'obtention de ces conjugués, ainsi que des compositions pharmaceutiques les contenant et l'utilisation desdits conjugués dans le traitement d'états pathologiques.
Belinka Benjamin A.
Pachence James M.
Ramani Thulasi
Mbm Intellectual Property Law Llp
Vectramed Inc.
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