Enzymatically amplified piezoelectric specific binding assay

C - Chemistry – Metallurgy – 12 – Q

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167/44, 150/8

C12Q 1/68 (2006.01) C12Q 1/28 (2006.01) G01N 27/00 (2006.01) G01N 33/543 (2006.01) G01N 33/545 (2006.01)

Patent

CA 1332221

ABSTRACT A quartz crystal microbalance assay in which the binding of analyte to a surface on or near a quartz crystal microbalance (QCM) is detected by a conjugate which comprises an enzyme capable of catalyzing the conversion of a substrate to a product capable of accummulating on or reacting with a surface of the QCM leading to a mass change and, hence, a change in resonant frequency.

602569

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