C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 17/06 (2006.01) C07K 1/107 (2006.01) C07K 16/40 (2006.01) C07K 17/00 (2006.01) C12N 9/96 (2006.01) C12N 11/00 (2006.01) C12N 11/06 (2006.01) G01N 33/532 (2006.01) G01N 33/543 (2006.01) G01N 33/58 (2006.01)
Patent
CA 2063434
2063434 9100296 PCTABS00003 The invention provides a means for attaching a label, support or bioactive agent to the protein at a site that is remote from the active site of the protein. More specifically the invention is directed to a method for the attachment of an amino acid, amino acid derivative, amine and alcohol nucleophile to the carboxyl terminus of a protein. In one embodiment, an exopeptidase enzyme is utilized to attach a labeled nucleophile to a protein such as an antibody. In other embodiments, the invention is directed to a method for the attachment of a protein to an immobilization support and to a method for the attachment of a bioactive agent to a protein.
Breddam Klaus
Coolidge Thomas R.
Lewis William
Schuster Sheldon M.
Stout Jay
Bionebraska Inc.
Gowling Lafleur Henderson Llp
The Board Of Regents Of The University Of Nebraska
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