Enzymatically debranched starches as tablet excipients

Details Enzymatically debranched starches as tablet excipients Enzymatically debranched starches as tablet excipients

C - Chemistry, Metallurgy

12

P

195/138, 167/168

C12P 19/16 (2006.01) A61K 47/36 (2006.01)

Patent

CA 2032385

ABSTRACT An excipient, and in particular, a binder, useful in the manufacture of tablets, pellets, capsules, or granules for the delivery of active agents, is prepared by the enzymatic debranching of starch with an alpha-1,6-D- glucanohydrolase to yield at least 20%, by weight, short chain amylose. A process for preparing short chain amylose from the debranched starch is provided. The starch may be fully or partially debranched and may further comprise amylopectin, partially debranched amylopectin, long chain amylose, or a combination thereof, and may be modified by derivatization, crosslinking, dextrinization or conversion. This starch is useful in the manufacture of tablets by direct compression or other tabletting methods.

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