Enzymatically-produced dimeric il-2 and a nerve-derived...

Details Enzymatically-produced dimeric il-2 and a nerve-derived... Enzymatically-produced dimeric il-2 and a nerve-derived...

C - Chemistry, Metallurgy

12

N

C12N 9/10 (2006.01) A61K 38/20 (2006.01) A61K 38/45 (2006.01) C07K 14/55 (2006.01) C12P 21/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2119873

ABSTRACT The invention provides a new nerve-derived transglutaminase enzyme that converts immune-derived IL-2 to dimeric IL-2 having oligodendxocyte cytotoxic activity. Both the nerve- derived transglutaminase and the dimeric mammalian, e.g. human, IL-2, are for use as active ingredients in pharmaceutical compositions for inducing and facilitating regeneration of injured nerves of the central nervous system in mammals. -52-

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