C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 229/08 (2006.01) C07B 61/00 (2006.01) C07C 227/20 (2006.01) C07C 271/22 (2006.01) C07K 1/04 (2006.01) C12P 1/00 (2006.01) C12P 13/04 (2006.01)
Patent
CA 2258551
The invention concerns an enzymatically removable linker, bonded to a solid phase on which organic compounds are synthesized via a functional group. The invention is characterized in that the linker contains an identification point for a hydrolytic enzyme and disintegrates by reacting with the enzyme such that no molecular parts of the linker remain in the synthesized product, and such that the identification point for the enzyme and the point at which the synthesis product is released via the disintegration of the linker are different.
L'invention concerne un segment de liaison séparable par voie enzymatique, lié sur une phase solide, sur lequel des composés organiques synthétisés par l'intermédiaire d'un groupe fonctionnel, qui se caractérise en ce que le segment de liaison contient un point d'identification pour une enzyme hydrolitique et se désagrège avec l'enzyme de manière qu'il ne subsiste aucune part moléculaire du segment de liaison dans le produit synthétisé et que le point d'identification de l'enzyme et le point auquel le produit de synthèse est libéré par l'intermédiaire de la désagrégation du segment de liaison soient différents.
Grether Uwe
Sauerbrei Bernd
Waldmann Herbert
Basf Aktiengesellschaft
Robic
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