Enzyme activity profiles

Details Enzyme activity profiles Enzyme activity profiles

G - Physics

01

N

G01N 33/574 (2006.01) C12N 9/64 (2006.01) C12Q 1/34 (2006.01)

Patent

CA 2468457

Methods and compositions are provided for evaluating cellular status related to neoplasia. Affinity based probes, particularly having fluorophosphonates as a reactive functionality, are employed that react with a family of enzymes having a common catalytic activity, particularly serine/threonine hydrolases. The probe(s) are combined with the cell components and resulting conjugates are characterized, where the profile of reaction indicates cellular status. A novel serine/threonine hydrolase enzyme is provided.

Cette invention concerne des méthodes et des compositions permettant d'apprécier un état cellulaire en rapport avec une néoplasie. A cette fin, on utilise des sondes à affinité, en particulier des fluorophosphonates, à fonctionnalité réactive, qui réagissent avec une famille d'enzymes présentant une activité catalytique commune, en particulier des hydrolases de sérine/thréonine. La ou les sondes sont combinées avec des composants cellulaires et les conjugués qui en résultent sont caractérisés, le profil de la réaction renseignant sur l'état cellulaire. L'invention concerne une nouvelle enzyme, l'hydrolase de sérine/thréonine.

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