Enzyme and its use in preparing (s)-pipecolic acid

Details Enzyme and its use in preparing (s)-pipecolic acid Enzyme and its use in preparing (s)-pipecolic acid

C - Chemistry, Metallurgy

12

N

C12N 9/80 (2006.01) C12N 1/20 (2006.01) C12P 17/12 (2006.01) C12P 41/00 (2006.01)

Patent

CA 2172954

An enzyme having acylase activity capable of hydrolysing N-acetyl-(R,S)- pipecolic acid stereo-selectively, to give (S)-pipecolic acid, wherein said activity is greater than that on N-acetyl-S-proline, at pH 7.5, 25 °C, and substrate concentration 20 g/l, in 75 mM Tris buffer.

Enzyme à activité acylasique capable d'hydrolyser stéréosélectivement l'acide N-acétyl-(R, S)-pipécolique en vue de l'obtention d'acide (S)-pipécolique, ladite activité étant supérieure à celle de la N-acétyl-S-proline à 25 DEG C et pour un pH de 7,5 et une concentration du substrat de 20 g/l dans un tampon tris de 75 mM.

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