C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 7/40 (2006.01) C12P 13/04 (2006.01) C12P 41/00 (2006.01)
Patent
CA 2059075
AE 6877 A B S T R A C T Enzyme-catalysed preparation of an .alpha.-substituted optically active carboxylic acid, using enantioselective hydrolysis of a mixture of the enantiomers of the corresponding amide, an Ochrobactrum anthropi or an Klebsiella sp. being used as the enzyme. During the hydrolysis both the L-carboxylic acid and the remaining D-carboxylic acid amide are obtained with high optical purity and high yield, while the activity of the micro-organism is high. A large number of a-substituted carboxylic acid amides with a remarkable structural variety can be hydrolysed in this manner.
Van Den Tweel Wilhelmus J. J.
Van Dooren Theodorus J. G. M.
Dsm N.v.
Fetherstonhaugh & Co.
Van Den Tweel Wilhelmus J. J.
Van Dooren Theodorus J. G. M.
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