Enzyme catalyzed anti-infective therapeutic agents

A - Human Necessities – 61 – K

Patent

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Details

A61K 47/48 (2006.01) A61P 31/12 (2006.01) C12Q 1/18 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2379834

This invention provides a method for selectively inhibiting an infectious agent or a cell infected by an infectious agent by contacting the infectious agent or the cell infected with the agent with a prodrug that is selectively converted to a toxin by an activating enzyme expressed by the infectious agent. The activating enzyme is selective for the enzyme expressed by the infectious agent as compared to the same or similar enzyme expressed by the host cell or other infectious agents. The activating agent is not inhibited nor inactivated by the prodrug. Screens for identifying prodrugs are also provided herein.

L'invention concerne une méthode permettant d'inhiber sélectivement un agent infectieux ou une cellule infectée par un agent infectieux en mettant ledit agent infectieux ou ladite cellule infectée par l'agent en contact avec un promédicament qui est sélectivement converti en une toxine au moyen d'un enzyme d'activation exprimé par l'agent infectieux. Cet enzyme d'activation est sélectif pour l'enzyme exprimé par l'agent infectieux en comparaison avec l'enzyme identique ou similaire exprimé par la cellule hôte ou d'autres agents infectieux. L'agent d'activation n'est ni inhibé ni inactivé par le promédicament. L'invention concerne également des cribles permettant d'identifier des promédicaments.

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