C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 13/04 (2006.01) A61K 8/44 (2006.01) A61Q 11/00 (2006.01) C07C 231/02 (2006.01) C11D 1/52 (2006.01) C11D 3/32 (2006.01) C12P 13/02 (2006.01)
Patent
CA 2057041
2057041 9014429 PCTABS00002 Compounds of general formula (I) or (II), wherein R is an optionally substituted alkyl group with 3-23 carbon atoms, and R1 is hydrogen or an optionally substituted branched or straight-chain, saturated or unsaturated, aliphatic or aromatic hydrocarbon group, are prepared by reacting a compound of the general formula (III): RCOOR2, wherein R2 is H or an alkyl group with 1-6 carbon atoms, and R is as defined above, with a compound of general formula (IV), wherein R1 is as defined above, in the presence of an enzyme capable of catalysing the formation of amide bonds, in particular a lipase. The amide group may be removed from the compound (I) by means of a second enzyme capable of selectively cleaving amide bonds, e.g. a carboxypeptidase, resulting in the compound (II).
Bjorkling Frederik
Godtfredsen Sven E.
Novo Nordisk A/s
Ridout & Maybee Llp
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