Enzyme-catalyzed racemic cleavage of primary amines

Details Enzyme-catalyzed racemic cleavage of primary amines Enzyme-catalyzed racemic cleavage of primary amines

C - Chemistry, Metallurgy

12

P

C12P 41/00 (2006.01) C07C 213/08 (2006.01) C12P 13/02 (2006.01) C07C 217/08 (2006.01)

Patent

CA 2341345

The invention relates to a method for the racemic cleavage of alkoxy- substituted primary amines by reaction with an ester in the presence of a lipase and subsequent separation of the resulting optically active amide from the optically active unreacted amine. This is possibly followed by hydrolysis of the optically active amide, separation of the resulting optically active amine from the acid at the origin of the ester, racemization and recirculation of the undesirable enantiomer of the amine and esterification and recirculation of the acid.

La présente invention concerne un procédé de dissociation des racémates d'amines primaires à substitution alcoxy, par réaction avec un ester, en présence d'une lipase, cette réaction étant suivie de la séparation, de l'acide à l'origine de l'ester, de l'amine optiquement active ainsi formée, puis de la racémisation et du recyclage de l'énantiomère non souhaité de l'amine, ainsi que de l'estérification et du recyclage de l'acide.

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