Enzyme derivatives

Details Enzyme derivatives Enzyme derivatives

C - Chemistry, Metallurgy

12

N

195/126, 167/103

C12N 9/70 (2006.01) C07K 14/315 (2006.01) C12N 9/99 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1174621

- ABSTRACT - An enzyme derivative comprises a binary complex between streptokinase and plasminogen in which the catalytic site essential for fibrinolytic activity is blocked by a group which is removable by hydrolysis such that the pseudo-first order rate constant for hydrolysis of the derivative is in the range 10-6sec-1 to 10-3sec-1 in isotonic aqueous media at pH 7.4 at 37°C, and is useful in the treatment of venous thrombosis.

363957

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