Enzyme disruption of bacterial biofilms

Details Enzyme disruption of bacterial biofilms Enzyme disruption of bacterial biofilms

A - Human Necessities

61

K

A61K 38/48 (2006.01) A01N 63/00 (2006.01) A61L 2/00 (2006.01) A61L 27/14 (2006.01) A61L 27/34 (2006.01) A61L 27/54 (2006.01) A61L 29/04 (2006.01) A61L 29/08 (2006.01) A61L 29/16 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2476288

Methods for treating patients in which damaged tissue or an indwelling prosthetic device or catheter has a bacterial biofilm growing thereon, to at least partially disrupt said biofilm, by administering at least one antibacterial enzyme that is lethal or damaging to the biofilm-forming bacteria in an amount that is effective to at least partially disrupt the biofilm upon contact therewith. Methods for prophylactically treating a patient, and methods for disinfecting or sterilizing a surface ex-vivo to remove a biofilm or prevent biofilm growth are also disclosed, as well as implantable articles susceptible to biofilm growth to which a prophylactic coating of an antibacterial enzyme has been applied.

Procédés pour traiter les patients chez lesquels un biofilm bactérien pousse sur le tissu endommagé ou le cathéter prosthétique implanté, de manière à interrompre au moins partiellement ledit biofilm, par l'administration d'au moins une enzyme antibactérienne qui est fatale ou dangereuse pour les bactéries formatrices de film, dans des quantités efficaces pour interrompre au moins partiellement le film biologique qui se situe entre elles. L'invention concerne des procédés prophylactiques pour traiter un patient, et des procédés pour désinfecter ou stériliser une surface ex-vivo pour évacuer un biofilm ou empêcher la croissance d'un biofilm ainsi que des articles implantables sensibles à la croissance du film biologique auquel on a appliqué une enzyme antibactérienne.

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