C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 307/88 (2006.01) C07D 405/12 (2006.01) C07D 473/08 (2006.01) C07H 21/00 (2006.01) C07J 41/00 (2006.01) G01N 33/53 (2006.01) G01N 33/535 (2006.01) G01N 33/58 (2006.01) G01N 33/78 (2006.01) G01N 33/94 (2006.01)
Patent
CA 2341263
The present invention provides a method for the measurement of an analyte in biological samples whereby an uncompetitive inhibitor is coupled to a ligand and utilized in a homogeneous assay. The analyte can be a drug or drug derivative, hormone, polypeptide, or oligonucleotide. The present invention also provides novel compounds, assay reagents and packaged kits useful for performing such measurements.
La présente invention concerne une méthode permettant de mesurer un analyte dans des échantillons biologiques, laquelle méthode consiste à coupler un inhibiteur non compétitif à un ligand afin d'utiliser ledit inhibiteur dans un dosage homogène. L'analyte peut être un médicament ou un dérivé de médicament, une hormone, un polypeptide ou un oligonucléotide. La présente invention concerne également de nouveaux composés, réactifs de dosage et kits permettant de mettre en oeuvre de telles mesures.
Dorn Allan R.
Ghoshal Mitali
Hawley Ronald C.
Hoess Eva
Huber Erasmus
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Roche Diagnostics Corporation
Roche Diagnostics Gmbh
Roche Diagnostics Operations Inc.
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