Enzyme inhibitors

Details Enzyme inhibitors Enzyme inhibitors

C - Chemistry, Metallurgy

07

K

530/7.06, 530/5.

C07K 7/06 (2006.01) C07K 5/02 (2006.01) C07K 5/10 (2006.01) C07K 14/75 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1322078

20870-1037 ABSTRACT Peptide analogues of formula Image (I) wherein X and W are terminal groups optionally including further amino acyl groups; Y where present is glycine phenylalanine or other lipophilic amino acid residue; Z is glycine N-methyl alanine valine proline or a ring homologue of proline; A is a 'hydroxy' 'reduced' or preferably 'keto' dipeptide analogue residue of which the first residue is either arginine or has the side chain termi- nal amidino group of arginine and the second is a glycine alanine or related residue with a hydrocarbon side chain optionally hydroxy terminated; Arg or Pro and Arg where present are option- ally substituted; and B where present is valine proline or a group -NH-(CH2)n-CO- (n = 0 - 5), or with W represents an aminoalcohol; and wherein optionally the terminal groups are linked to give a cyclic structure are useful inhibitors of thrombogenesis.

448562

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