Enzyme inhibitors

Details Enzyme inhibitors Enzyme inhibitors

A - Human Necessities

61

K

A61K 31/18 (2006.01) A01N 41/06 (2006.01) A61P 31/04 (2006.01) A61P 31/10 (2006.01) C07C 311/13 (2006.01) C07C 311/21 (2006.01) C07C 311/29 (2006.01) C07C 311/46 (2006.01) C07C 317/14 (2006.01)

Patent

CA 2387593

Bissulfonamide derivatives of formula (I) are capable of inhibiting: a) the biosynthesis of aromatic amino acids via the shikimate pathway and b) the catabolism of quinic acid, wherein: Ar is an aryl or heteroaryl group; R1 and R2 are the same or different and each represent hydrogen or alkyl or R1 and R2 together form a C1-C3 alkylene group, -CO- or -CS-; and R3 and R4 are the same or different and each represent -alkyl-aryl, -alkyl-heteroaryl, -alkenyl-aryl, -alkenyl-heteroaryl, -alkynyl-aryl-alkynyl-heterorayl, aryl or heteroaryl.

Dérivés de bissulfonamide représentés par la formule (I) et capables d'inhiber (a) la biosynthèse d'acides aminés aromatiques par l'intermédiaire du trajet de shikimate et (b) le catabolisme de l'acide kuinique, dans laquelle: Ar représente un groupe aryle ou hétéroaryle; R¿1? et R¿2? sont semblables ou différents et représentent chacun hydrogène ou alkyle ou R¿1? et R¿2? ensemble constituent un groupe alkylène C¿1?-C¿3?, -CO- ou -CS-; R¿3? et R¿4? sont semblables ou différents et représentent chacun alkylaryle, alkylhétéroaryle, alkénylaryle, alkénylhétéroaryle, alkynylaryle, alkynylhétéroaryle, aryle ou hétéroaryle.

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