A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/55 (2006.01) A61K 31/382 (2006.01) A61K 31/4418 (2006.01) A61K 31/4433 (2006.01) A61P 25/28 (2006.01) C12N 9/99 (2006.01)
Patent
CA 2579768
The present invention relates to inhibitors of insulin-regulated aminopeptidase (IRAP) and methods for inhibiting same, as well as compositions comprising said inhibitors. In particular, the inhibitors of the present invention may be useful in therapeutic applications including enhancing memory and learning functions, regulating cellular glucose uptake and homeostasis, inducing labour and lactation, and other disorders or conditions wherein excessive or undesirable IRAP activity is implicated.
L'invention concerne des inhibiteurs de l'aminopeptidase régulées par l'insuline (IRAP) et des procédés pour les inhiber, ainsi que des compositions comprenant lesdits inhibiteurs. Les inhibiteurs de l'invention peuvent être utilisés, en particulier, dans des applications thérapeutiques comprenant l'amélioration de la mémoire et des fonctions d'apprentissage, la régulation de la fixation cellulaire du glucose et l'homéostasie, notamment le travail et la lactation, et d'autres troubles ou états pathologiques, dans lesquels une activité de l'IRAP est excessive ou non souhaitée.
Albiston Anthony Lloyd
Chai Siew Yeen
Mendelsohn Frederick A. O.
Morton Craig J.
Ng Hooi Ling
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Howard Florey Institute Of Experimental Physiology And Medicine
St. Vincent's Institute Of Medical Research
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