Enzyme-inhibitory griseolic acid derivatives, and their use

Details Enzyme-inhibitory griseolic acid derivatives, and their use Enzyme-inhibitory griseolic acid derivatives, and their use

C - Chemistry, Metallurgy

12

P

195/122.5, 260/2

C12P 19/40 (2006.01) C07H 19/02 (2006.01) C07H 19/16 (2006.01) C12N 1/20 (2006.01)

Patent

CA 1252058

ABSTRACT ENZYME-INHIBITORY GRISEOLIC ACID DERIVATIVES, AND THEIR USE Dihydrodesoxygriseolic acid, which has the formula: Image (I) pharmaceutically acceptable and salts and esters thereof may be prepared by cultivating a suitable strain of Streptomyces, e.g. Streptomyces griseoaurantiacus No. 43894, and, if necessary, salifying or esterifying the free acid. These compounds inhibit the activity of various cyclic nucleotide phosphodiesterases, particularly cAMP PDE, and, as a result of this, have a variety of physiological activities and uses.

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